Molecular weight (DA)
59kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR17. AA range:196-245
Specificity
GPR17 Polyclonal Antibody detects endogenous levels of GPR17 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.,
Function
function:Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.,
Protein name
Uracil nucleotide/cysteinyl leukotriene receptor
Other name
GPR17; Uracil nucleotide/cysteinyl leukotriene receptor; UDP/CysLT receptor; G-protein coupled receptor 17; P2Y-like receptor; R12
Human protein sequence Database
Q13304
Mouse protein sequence database
Q6NS65
Rat protein sequence database
Q09QM4
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.
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