Molecular weight (DA)
21kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Cardiotrophin-1. AA range:31-80
Specificity
Cardiotrophin-1 Polyclonal Antibody detects endogenous levels of Cardiotrophin-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],
Function
function:Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.,similarity:Belongs to the IL-6 superfamily.,tissue specificity:Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.,
Protein name
Cardiotrophin-1
Abbreviation
Cardiotrophin-1
Other name
CTF1; Cardiotrophin-1; CT-1
Fields
>>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway
Human protein sequence Database
Q16619
Mouse protein sequence database
Q60753
Rat protein sequence database
Q63086
Cellular localization
Secreted.
Tissue expression
Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.
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