Molecular weight (DA)
Calculated MW: 46 kDa; Observed MW: 46 kDa
Immunogen
Fusion protein of human TNFRSF11B Purification Affinity Purified Conjugation
Unconjugated Modification Unmodified Form Liquid
Dilution rate
WB: 1/500-1/1000 IHC: 1/50-1/100
Purification process (Immunogen)
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Abbreviation
TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin
Human gene ID
SwissProt ID
O00300
Human protein sequence Database
Gene ID
4982
Mouse protein sequence database
Rat protein sequence database
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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