Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CD153. AA range:71-120
Specificity
CD30-L Polyclonal Antibody detects endogenous levels of CD30-L protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
Function
function:Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,
Protein name
Tumor necrosis factor ligand superfamily member 8
Other name
TNFSF8; CD30L; CD30LG; Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L; CD antigen CD153
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
P32971
Mouse protein sequence database
P32972
Rat protein sequence database
Cellular localization
Membrane; Single-pass type II membrane protein.
Tissue expression
Brain,Thymus,
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