Molecular weight (DA)
21kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1-80
Specificity
8ODP Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer is
Function
catalytic activity:8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.,developmental stage:In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.,function:Antimutagenic. Responsible for preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions.,polymorphism:A polymorphism between Met-1 and Met-19 removes a stop codon before the initiation codon for isoform p22 and gives rise to the production of isoform p26. The allele frequency of isoform p26 is about 20%.,PTM:The N-terminus is blocked.,similarity:Belongs to the Nudix hydrolase family.,tissue specificity:Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.,
Protein name
7,8-dihydro-8-oxoguanine triphosphatase (EC 3.6.1.55) (2-hydroxy-dATP diphosphatase) (EC 3.6.1.56) (8-oxo-dGTPase) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1)
Human protein sequence Database
P36639
Mouse protein sequence database
P53368
Rat protein sequence database
P53369
Cellular localization
[Isoform p18]: Cytoplasm, cytosol . Mitochondrion matrix . Nucleus . Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328). A very small amount of the protein is associated with nuclei (PubMed:7782328). .; [Isoform p26]: Mitochondrion matrix .
Tissue expression
Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
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