Molecular weight (DA)
57kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human LAG3. AA range:91-140
Specificity
CD223 Polyclonal Antibody detects endogenous levels of CD223 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008],
Function
function:Involved in lymphocyte activation. Binds to HLA class-II antigens.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:On cell surface of activated NK and T-lymphocytes.,
Protein name
Lymphocyte activation gene 3 protein
Other name
LAG3; FDC; Lymphocyte activation gene 3 protein; LAG-3; Protein FDC; CD223
Human protein sequence Database
P18627
Mouse protein sequence database
Q61790
Rat protein sequence database
Q5BK54
Cellular localization
[Lymphocyte activation gene 3 protein]: Cell membrane ; Single-pass type I membrane protein .; [Secreted lymphocyte activation gene 3 protein]: Secreted . Produced following cleavage of the main chain. .
Tissue expression
Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.
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