Molecular weight (DA)
90kD
Immunogen
Purified recombinant human p90RSK protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of p90RSK and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb dilution 1:1000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
ribosomal protein S6 kinase A1(RPS6KA1) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-380, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic s
Other name
90 kDa ribosomal protein S6 kinase 1;dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1;dJ590P13.1;EC 2.7.11.1;HU 1;HU1;KS6A1_HUMAN;MAP kinase activated protein kinase 1a;MAP kinase-activated protein kinase 1a;MAPK-activated protein kinase 1a;MAPKAP kinase 1a;MAPKAPK-1a;MAPKAPK1A;MGC79981;Mitogen-activated protein kinase-activated protein kinase 1A;OTTHUMP00000004113;p90 RSK1;p90-RSK 1;p90rsk;p90RSK1;p90S6K;pp90RSK1;Ribosomal protein S6 kinase 90kD 1;Ribosomal protein S6 kinase 90kD polypeptide 1;Ribosomal protein S6 kinase 90kDa polypeptide 1;Ribosomal protein S6 kinase alpha 1;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase polypeptide 1;Ribosomal S6 kinase 1;RPS6K1 alpha;rps6ka;Rps6ka1;RSK 1;RSK 1 p90;RSK;RSK-1;RSK1;S6K alpha 1;S6K-alpha-1.
Fields
>>MAPK signaling pathway;>>Oocyte meiosis;>>mTOR signaling pathway;>>Thermogenesis;>>Long-term potentiation;>>Neurotrophin signaling pathway;>>Progesterone-mediated oocyte maturation;>>Insulin resistance;>>Yersinia infection;>>Chemical carcinogenesis - receptor activation
Human protein sequence Database
Q15418
Mouse protein sequence database
P18653
Rat protein sequence database
Cellular localization
Nucleus. Cytoplasm.
Tissue expression
Colon,Epithelium,
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