Immunogen
Synthesized peptide derived from human GST-Pi
Specificity
The antibody can specifically recognize human GST-Pi protein.
Source
Monoclonal Mouse IgG2b, Kappa
Formulation
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Dilution rate
IHC-p 1:200-400, WB 1:200-1000,
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008],
Function
catalytic activity:RX + glutathione = HX + R-S-glutathione.,function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the GST superfamily. Pi family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer.,
Gene Name
GSTP1 FAEES3 GST3
Protein name
Deafness;Deafness X-linked 7;DFN7;FAEES3;Fatty Acid Ethyl Ester Synthase III;Glutathione S Transferase 3;Glutathione S Transferase Pi;Glutathione S-transferase P;Glutathione S-transferase pi 1;GST cla
Other name
Deafness;Deafness X-linked 7;DFN7;FAEES3;Fatty Acid Ethyl Ester Synthase III;Glutathione S Transferase 3;Glutathione S Transferase Pi;Glutathione S-transferase P;Glutathione S-transferase pi 1;GST class-pi;GST3;GSTP;Gstp1;GSTP1-1;GSTP1_HUMAN;PI;X linked 7
Fields
>>Glutathione metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Drug metabolism - cytochrome P450;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Platinum drug resistance;>>Pathways in cancer;>>Chemical carcinogenesis - DNA adducts;>>Prostate cancer;>>Hepatocellular carcinoma;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P09211
Mouse protein sequence database
P19157
Rat protein sequence database
P04906
Cellular localization
Cytoplasmic
Tissue expression
Esophageal squamous cell carcinoma
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