Immunogen
Synthesized peptide derived from human Synaptophysin
Specificity
The antibody can specifically recognize human Synaptophysin protein.
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Dilution rate
IHC-p 1:200-400, WB 1:200-1000,
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011],
Function
domain:The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.,function:Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.,online information:Synaptophysin entry,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the synaptophysin/synaptobrevin family.,similarity:Contains 1 MARVEL domain.,subunit:Homohexamer or homotetramer.,tissue specificity:Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.,
Protein name
Major synaptic vesicle protein p38;MRX96;MRXSYP;Syn p38;Synaptophysin;Syp;SYPH;SYPH_HUMAN;SypI
Abbreviation
Synaptophysin
Other name
Major synaptic vesicle protein p38;MRX96;MRXSYP;Syn p38;Synaptophysin;Syp;SYPH;SYPH_HUMAN;SypI
Human protein sequence Database
P08247
Mouse protein sequence database
Q62277
Rat protein sequence database
P07825
Cellular localization
Cytoplasmic
Tissue expression
Pancreas/ Colon
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