Immunogen
Synthesized peptide derived from human PMEL
Specificity
The antibody can specifically recognize human PMEL protein.
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Dilution rate
IHC-p 1:200-400, WB 1:200-1000,
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011],
Function
function:Could be a melanogenic enzyme. Could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.,similarity:Belongs to the Pmel-17/NMB family.,similarity:Contains 1 PKD domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subcellular location:Probably product of proteolytic cleavage.,tissue specificity:Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas.,
Gene Name
PMEL D12S53E PMEL17 SILV
Protein name
95 kDa melanocyte specific secreted glycoprotein;95 kDa melanocyte-specific secreted glycoprotein;D12S53E;gp100;M-beta;ME20;ME20 M/ME20 S;ME20-M;ME20-S;ME20M;ME20M/ME20S;ME20S;Melanocyte lineage speci
Other name
95 kDa melanocyte specific secreted glycoprotein;95 kDa melanocyte-specific secreted glycoprotein;D12S53E;gp100;M-beta;ME20;ME20 M/ME20 S;ME20-M;ME20-S;ME20M;ME20M/ME20S;ME20S;Melanocyte lineage specific antigen GP100;Melanocyte protein mel 17;Melanocyte protein Pmel 17;Melanocyte protein Pmel 17 precursor;Melanocytes lineage-specific antigen GP100;Melanoma associated ME20 antigen;Melanoma gp100;Melanoma-associated ME20 antigen;Melanosomal matrix protein 17;Melanosomal matrix protein17;P1;p100;p26;PMEL 17;PMEL;PMEL_HUMAN;PMEL17;Premelanosome protein;Secreted melanoma-associated ME20 antigen;SI;SIL;SILV;Silver (mouse homolog) like;Silver homolog;Silver locus protein homolog;Silver, mouse, homolog of
Human protein sequence Database
P40967
Mouse protein sequence database
Q60696
Rat protein sequence database
Cellular localization
Cytoplasmic
Tissue expression
Skin/ Melanoma
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