Immunogen
Synthetic peptide corresponding to aa (Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser) of human BNP, conjugated to KLH.
Specificity
BNP Monoclonal Antibody detects endogenous levels of BNP protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014],
Function
function:Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body's salt and water balance. Improves heart function.,online information:Brain natriuretic peptide entry,pharmaceutical:Available under the name Nesiritide (Scios). Used for the treatment of heart failure.,similarity:Belongs to the natriuretic peptide family.,subunit:Interacts with NPR3.,tissue specificity:Brain and also in atria, but at much lower levels than ANP.,
Protein name
Natriuretic peptides B
Other name
NPPB; Natriuretic peptides B; Gamma-brain natriuretic peptide
Fields
>>cGMP-PKG signaling pathway;>>Vascular smooth muscle contraction;>>Thermogenesis
Human protein sequence Database
P16860
Mouse protein sequence database
P40753
Rat protein sequence database
Cellular localization
[NT-proBNP]: Secreted . Detected in blood. .; [proBNP(3-108)]: Secreted . Detected in blood. .; [Brain natriuretic peptide 32]: Secreted . Detected in blood. .; [BNP(3-32)]: Secreted . Detected in blood. .
Tissue expression
[Brain natriuretic peptide 32]: Detected in the cardiac atria (at protein level) (PubMed:2138890, PubMed:2136732). Detected in the kidney distal tubular cells (at protein level) (PubMed:9794555).
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