Immunogen
Purified recombinant fragment of human IL-11 expressed in E. Coli.
Specificity
IL-11 Monoclonal Antibody detects endogenous levels of IL-11 protein.
Formulation
Purified antibody in PBS containing 0.03% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012],
Function
function:Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.,online information:Clinical information on Neumega,online information:Interleukin-11 entry,pharmaceutical:Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.,similarity:Belongs to the IL-6 superfamily.,
Protein name
Interleukin-11
Other name
IL11; Interleukin-11; IL-11; Adipogenesis inhibitory factor; AGIF; Oprelvekin
Fields
>>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>Rheumatoid arthritis
Human protein sequence Database
P20809
Mouse protein sequence database
P47873
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Bone marrow,Prostate,
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