Immunogen
Purified recombinant fragment of IL-2 expressed in E. Coli.
Specificity
IL-2 Monoclonal Antibody detects endogenous levels of IL-2 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008],
Function
disease:A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.,function:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.,online information:Interleukin-2 entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.,similarity:Belongs to the IL-2 family.,
Protein name
Interleukin-2
Other name
IL2; Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>PI3K-Akt signaling pathway;>>C-type lectin receptor signaling pathway;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>Intestinal immune network for IgA production;>>Type I diabetes mellitus;>>Yersinia infection;>>Chagas disease;>>Measles;>>Human T-cell leukemia virus 1 infection;>>Coronavirus disease - COVID-19;>>Pathways in cancer;>>Autoimmune thyroid disease;>>Inflammatory bowel disease;>>Allograft rejection;>>Graft-versus-host disease
Human protein sequence Database
P60568
Mouse protein sequence database
P04351
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Blood,PCR rescued clones,Placenta,Spleen,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车