Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Inhibin beta-C. AA range:80-129
Specificity
Inhibin β-C Polyclonal Antibody detects endogenous levels of Inhibin β-C protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016],
Function
function:Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.,similarity:Belongs to the TGF-beta family.,subunit:Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.,tissue specificity:Expressed in benign prostatic hyperplasia.,
Protein name
Inhibin beta C chain
Other name
INHBC; Inhibin beta C chain; Activin beta-C chain
Fields
>>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells
Human protein sequence Database
P55103
Mouse protein sequence database
P55104
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed in benign prostatic hyperplasia.
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