Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PTX3. AA range:1-50
Specificity
Ptx3 Polyclonal Antibody detects endogenous levels of Ptx3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016],
Function
function:Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.,induction:By interleukin-1 beta and TNF-alpha.,PTM:Glycosylated.,similarity:Contains 1 pentaxin domain.,subunit:Homooctamer; disulfide-linked. Binds to C1q.,
Protein name
Pentraxin-related protein PTX3
Other name
PTX3; TNFAIP5; TSG14; Pentraxin-related protein PTX3; Pentaxin-related protein PTX3; Tumor necrosis factor alpha-induced protein 5; TNF alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; TSG-14
Human protein sequence Database
P26022
Mouse protein sequence database
P48759
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Brain,Endothelial cell,Foreskin,
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