Molecular weight (DA)
125kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RANBP17. AA range:145-194
Specificity
Ran BP-17 Polyclonal Antibody detects endogenous levels of Ran BP-17 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
RAN binding protein 17(RANBP17) Homo sapiens The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002],
Function
function:May function as a nuclear transport receptor.,similarity:Belongs to the exportin family.,subunit:Binds to nucleoporins and the GTP-bound form of Ran.,tissue specificity:Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.,
Protein name
Ran-binding protein 17
Other name
RANBP17; Ran-binding protein 17
Fields
>>Nucleocytoplasmic transport
Human protein sequence Database
Q9H2T7
Mouse protein sequence database
Q99NF8
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Nucleus, nuclear pore complex .
Tissue expression
Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.
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