Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from Rho GDIγ . at AA range: 110-190
Specificity
Rho GDIγ Polyclonal Antibody detects endogenous levels of Rho GDIγ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010],
Function
function:Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.,similarity:Belongs to the Rho GDI family.,tissue specificity:Primarily expressed in pancreas and brain.,
Protein name
Rho GDP-dissociation inhibitor 3
Other name
ARHGDIG; Rho GDP-dissociation inhibitor 3; Rho GDI 3; Rho-GDI gamma
Fields
>>Neurotrophin signaling pathway;>>Vasopressin-regulated water reabsorption
Human protein sequence Database
Q99819
Mouse protein sequence database
Q62160
Rat protein sequence database
Cellular localization
Cytoplasm.
Tissue expression
Primarily expressed in pancreas and brain.
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