Molecular weight (DA)
53kD
Immunogen
The antiserum was produced against synthesized peptide derived from human AChRalpha5. AA range:166-215
Specificity
AChRα5 Polyclonal Antibody detects endogenous levels of AChRα5 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010],
Function
disease:Genetic variations in CHRNA5 may be associated with susceptibility to lung cancer type 2 (LNCR2) [MIM:612052].,function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta).,
Protein name
Neuronal acetylcholine receptor subunit alpha-5
Other name
CHRNA5; NACHRA5; Neuronal acetylcholine receptor subunit alpha-5
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P30532
Mouse protein sequence database
Q2MKA5
Rat protein sequence database
P20420
Cellular localization
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
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