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ATP5G3 Polyclonal Antibody

Polyclonal antibody

Specification

BYab-16389

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Host
Reactiveness
Use
Molecular weight (DA)
Immunogen
The antiserum was produced against synthesized peptide derived from human ATP5G3. AA range:1-50
Specificity
ATP5G3 Polyclonal Antibody detects endogenous levels of ATP5G3 protein.
Source
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Background
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identi
Function
disease:This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).,function:Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.,miscellaneous:There are three gene
Gene Name
ATP5G3
Protein name
ATP synthase lipid-binding protein mitochondrial
Abbreviation
ATP5G3
Other name
ATP5G3; ATP synthase lipid-binding protein; mitochondrial; ATP synthase proteolipid P3; ATPase protein 9; ATPase subunit c
Fields
>>Oxidative phosphorylation;>>Metabolic pathways;>>Thermogenesis;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy
Human gene ID
518
Human protein sequence Database
P48201
Mouse gene ID
Mouse protein sequence database
P56384
Rat gene ID
114630
Rat protein sequence database
Q71S46
Cellular localization
Mitochondrion membrane; Multi-pass membrane protein.
Tissue expression
Liver,Subthalamic nucleus,
Storage
-20°C/1 year

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ATP5G3 Polyclonal Antibody

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