Molecular weight (DA)
210kD
Immunogen
The antiserum was produced against synthesized peptide derived from human KIF20B. AA range:1771-1820
Specificity
MPP1 Polyclonal Antibody detects endogenous levels of MPP1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IF/ICC 1:50-300; ELISA 1:2000-20000; IHC-p 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
KIF20B (Kinesin Family Member 20B) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF23.
Function
M phase of mitotic cell cycle, mitotic cell cycle, M phase, nuclear division, microtubule-based process, microtubule-based movement, cell cycle, cell cycle arrest, mitosis, regulation of mitosis, regulation of mitotic cell cycle, regulation of cell cycle process, cell cycle process, cell cycle phase, regulation of organelle organization, organelle fission, cell division,regulation of cell cycle, regulation of nuclear division,
Protein name
Kinesin-like protein KIF20B
Other name
KIF20B; KRMP1; MPHOSPH1; Kinesin-like protein KIF20B; Cancer/testis antigen 90; CT90; Kinesin-related motor interacting with PIN1; M-phase phosphoprotein 1; MPP1
Human protein sequence Database
Q96Q89
Mouse protein sequence database
Q80WE4
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Midbody . Cell projection, axon . Cell projection, growth cone . Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (PubMed:12740395). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:12740395, PubMed:17409436). A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase (PubMed:12740395). During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct
Tissue expression
Brain, ovary, kidney and testis (at protein level) (PubMed:12740395). Overexpressed in bladder cancer cells (at protein level) (PubMed:17409436). Expressed in testis. Overexpressed in bladder cancer cells (PubMed:17409436).
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