Molecular weight (DA)
24kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GJB7. AA range:21-70
Specificity
Connexin 25 Polyclonal Antibody detects endogenous levels of Connexin 25 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008],
Function
function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.,similarity:Belongs to the connexin family. Beta-type (group I) subfamily.,subunit:A connexon is composed of a hexamer of connexins.,tissue specificity:Weakly expressed in placenta.,
Protein name
Gap junction beta-7 protein
Other name
GJB7; CX25; Gap junction beta-7 protein; Connexin-25; Cx25
Human protein sequence Database
Q6PEY0
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction .
Tissue expression
Weakly expressed in placenta.
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