Immunogen
The antiserum was produced against synthesized peptide derived from human Mucin-14. AA range:201-250
Specificity
Endomucin Polyclonal Antibody detects endogenous levels of Endomucin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
endomucin(EMCN) Homo sapiens EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008],
Function
function:Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.,PTM:Highly O-glycosylated. Sialic acid-rich glycoprotein.,subcellular location:Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.,tissue specificity:Expressed in heart, kidney and lung.,
Other name
EMCN; EMCN2; MUC14; Endomucin; Endomucin-2; Gastric cancer antigen Ga34; Mucin-14; MUC-14
Human protein sequence Database
Q9ULC0
Mouse protein sequence database
Q9R0H2
Rat protein sequence database
Q6AY82
Cellular localization
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.; [Isoform 2]: Secreted .
Tissue expression
Expressed in heart, kidney and lung.
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