Molecular weight (DA)
66kD
Immunogen
Synthesized peptide derived from human ABCE1
Specificity
This antibody detects endogenous levels of ABCE1 at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway . Together with PELO and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes . Together with PELO and HBS1L, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway . Plays a role in the regulation of mRNA turnover (By similarity). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA . As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and i
Gene Name
ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40
Protein name
ATP-binding cassette sub-family E member 1 (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)
Human protein sequence Database
P61221
Mouse protein sequence database
P61222
Rat protein sequence database
Cellular localization
Cytoplasm . Mitochondrion . Localized to clusters of virus formation at the plasma membrane.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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