Molecular weight (DA)
56kD
Immunogen
Synthesized peptide derived from human HMGCS2
Specificity
This antibody detects endogenous levels of HMGCS2 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
Protein name
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)
Human protein sequence Database
P54868
Mouse protein sequence database
P54869
Rat protein sequence database
P22791
Cellular localization
Mitochondrion .
Tissue expression
Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle (PubMed:7893153, PubMed:21952825, PubMed:16940161). Not detected in brain (PubMed:21952825). ; [Isoform 3]: Highest expression detected in heart and skeletal muscle.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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