Molecular weight (DA)
58kD
Immunogen
Synthesized peptide derived from human RBM39
Specificity
This antibody detects endogenous levels of RBM39 at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
RNA-binding protein that acts as a pre-mRNA splicing factor . Acts by promoting exon inclusion via regulation of exon cassette splicing . Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).
Gene Name
RBM39 HCC1 RNPC2
Protein name
RNA-binding protein 39 (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1)
Human protein sequence Database
Q14498
Mouse protein sequence database
Q8VH51
Rat protein sequence database
Cellular localization
Nucleus speckle . Concentrated in nuclear speckles (PubMed:8227358). Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358). .
Tissue expression
Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain (PubMed:8227358). Expressed at intermediate level in kidney, liver and heart (PubMed:8227358).
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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