Molecular weight (DA)
83kD
Immunogen
Synthesized peptide derived from human SMURF1
Specificity
This antibody detects endogenous levels of SMURF1 at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS . Plays a role in dendrite formation by melanocytes .
Gene Name
SMURF1 KIAA1625
Protein name
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 6.3.2.-) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Human protein sequence Database
Q9HCE7
Mouse protein sequence database
Q9CUN6
Rat protein sequence database
Cellular localization
Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
Tissue expression
Expressed in melanocytes (PubMed:23999003).
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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