Molecular weight (DA)
52kD
Immunogen
Synthesized peptide derived from human PTPIP51
Specificity
This antibody detects endogenous levels of PTPIP51 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
Gene Name
FAM82A2 FAM82C PTPIP51 hucep-10 UNQ3122/PRO10274
Protein name
Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 5
Human protein sequence Database
Q96TC7
Mouse protein sequence database
Q3UJU9
Rat protein sequence database
Q66H15
Cellular localization
Mitochondrion outer membrane ; Single-pass membrane protein . Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. .
Tissue expression
Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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