Molecular weight (DA)
32kD
Immunogen
Synthesized peptide derived from human CNOT8
Specificity
This antibody detects endogenous levels of CNOT8 at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity
Gene Name
CNOT8 CALIF POP2
Protein name
CCR4-NOT transcription complex subunit 8 (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8)
Human protein sequence Database
Q9UFF9
Mouse protein sequence database
Q9D8X5
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus .
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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