Molecular weight (DA)
51kD
Immunogen
Synthesized peptide derived from human ASL
Specificity
This antibody detects endogenous levels of ASL at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues . Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway .
Protein name
Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase)
Human protein sequence Database
P04424
Mouse protein sequence database
Q91YI0
Rat protein sequence database
P20673
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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