Immunogen
The antiserum was produced against synthesized peptide derived from human GRAA. AA range:61-110
Specificity
Granzyme A Polyclonal Antibody detects endogenous levels of Granzyme A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|-Xaa- in small molecule substrates.,function:This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. May be involved in apoptosis.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subunit:Homodimer; disulfide-linked.,
Other name
GZMA; CTLA3; HFSP; Granzyme A; CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor; H factor; HF
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P12544
Mouse protein sequence database
P11032
Rat protein sequence database
Cellular localization
[Isoform alpha]: Secreted . Cytoplasmic granule . Delivered into the target cell by perforin. .
Tissue expression
Blood,Liver,T-cell,
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