Molecular weight (DA)
12kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TUSC2. AA range:41-90
Specificity
TUSC2 Polyclonal Antibody detects endogenous levels of TUSC2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008],
Function
function:May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.,PTM:Myristoylation is required for tumor suppressor activity.,similarity:Belongs to the TUSC2 family.,tissue specificity:Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.,
Protein name
Tumor suppressor candidate 2
Other name
TUSC2; C3orf11; FUS1; LGCC; PDAP2; Tumor suppressor candidate 2; Fusion 1 protein; Fus-1 protein; PDGFA-associated protein 2
Human protein sequence Database
O75896
Mouse protein sequence database
Q9WVF8
Rat protein sequence database
Cellular localization
mitochondrion,
Tissue expression
Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.
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