Molecular weight (DA)
32kD
Immunogen
Synthesized peptide derived from human KLF13 (Acetyl Lys166)
Specificity
This antibody detects endogenous levels of Human,Mouse KLF13 (Acetyl Lys166)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008],
Function
domain:The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.,function:Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.,PTM:Phosphorylated.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,tissue specificity:Ubiquitous.,
Gene Name
KLF13 BTEB3 NSLP1
Protein name
KLF13 (Acetyl Lys166)
Other name
Krueppel-like factor 13 (Basic transcription element-binding protein 3;BTE-binding protein 3;Novel Sp1-like zinc finger transcription factor 1;RANTES factor of late activated T-lymphocytes 1;RFLAT-1;Transcription factor BTEB3;Transcription factor NSLP1)
Human protein sequence Database
Q9Y2Y9
Mouse protein sequence database
Q9JJZ6
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Ubiquitous.
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