Molecular weight (DA)
35kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SFRS7. AA range:61-110
Specificity
9G8 Polyclonal Antibody detects endogenous levels of 9G8 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010],
Function
alternative products:Isoforms, often lacking the RS domain and differentially expressed in fetal tissues, may be involved in modulation of 9G8 function,function:Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro.,PTM:Extensively phosphorylated on serine residues in the RS domain.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 1 CCHC-type zinc finger.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2. Interacts with CCNL2 and CPSF6.,tissue specificity:Brain, liver, kidney and lung.,
Protein name
Serine/arginine-rich splicing factor 7
Other name
SRSF7; SFRS7; Serine/arginine-rich splicing factor 7; Splicing factor 9G8; Splicing factor; arginine/serine-rich 7
Fields
>>Spliceosome;>>Amyotrophic lateral sclerosis;>>Herpes simplex virus 1 infection
Human protein sequence Database
Q16629
Mouse protein sequence database
Q8BL97
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm .
Tissue expression
Brain, liver, kidney and lung.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车