Molecular weight (DA)
77kD
Immunogen
Synthesized peptide derived from the Internal region of human SCML2.
Specificity
SCML2 Polyclonal Antibody detects endogenous levels of SCML2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010],
Function
function:Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SCM family.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 MBT repeats.,tissue specificity:Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.,
Protein name
Sex comb on midleg-like protein 2
Other name
SCML2; Sex comb on midleg-like protein 2
Human protein sequence Database
Q9UQR0
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.
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