Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human CALB1. AA range:191-240
Specificity
Calbindin D28K Polyclonal Antibody detects endogenous levels of Calbindin D28K protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015],
Function
domain:This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.,function:Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.,online information:Calbindin entry,similarity:Belongs to the calbindin family.,similarity:Contains 5 EF-hand domains.,subunit:Interacts with RANBP9.,
Abbreviation
Calbindin D28K
Other name
CALB1; CAB27; Calbindin; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type
Fields
>>Endocrine and other factor-regulated calcium reabsorption
Human protein sequence Database
P05937
Mouse protein sequence database
P12658
Rat protein sequence database
P07171
Cellular localization
nucleus,cytosol,axon,dendrite,neuronal cell body,terminal bouton,synapse,extracellular exosome,
Tissue expression
Brain,Cerebellum,Kidney,Lung,Substantia nigra,
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