Molecular weight (DA)
46 62kD
Immunogen
Synthesized peptide derived from human GGT1 (heavy chain, Cleaved-Gly380)
Specificity
This antibody detects endogenous levels of Human GGT1 (heavy chain, Cleaved-Gly380, protein was cleaved amino acid sequence between 380-381 )
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014],
Function
catalytic activity:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.,disease:Defects in GGT1 are a cause of glutathionuria [MIM:231950]; also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease.,function:Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.,function:Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.,miscellaneous:Corresponds to the light chain of other
Protein name
GGT1 (heavy chain, Cleaved-Gly380)
Other name
Gamma-glutamyltranspeptidase 1 (GGT 1;EC 2.3.2.2;Gamma-glutamyltransferase 1;Glutathione hydrolase 1;EC 3.4.19.13;Leukotriene-C4 hydrolase;EC 3.4.19.14;CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain]
Fields
>>Taurine and hypotaurine metabolism;>>Glutathione metabolism;>>Arachidonic acid metabolism;>>Metabolic pathways
Human protein sequence Database
P19440
Mouse protein sequence database
Q60928
Rat protein sequence database
P07314
Cellular localization
Cell membrane ; Single-pass type II membrane protein .
Tissue expression
Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.; [Isoform 3]: Lung-specific.
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