Molecular weight (DA)
55kD
Immunogen
Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of TAB1(N-terminus) and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr
Function
function:May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with MAP3K7, XIAP and BIRC7.,tissue specificity:Ubiquitous.,
Abbreviation
TAB1(N-term)
Other name
2310012M03Rik;3'-Tab1;MAP3K7IP 1;MAP3K7IP1;MGC57664;Mitogen activated protein kinase kinase kinase 7 interacting protein 1;Mitogen-activated protein kinase kinase kinase 7-interacting protein 1;TAB 1;TAB1;TAB1_HUMAN;TAK1 binding protein 1;TAK1-binding protein 1;TGF beta activated kinase 1 binding protein 1;TGF-beta activated kinase 1/MAP3K7 binding protein 1;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;TGF-beta-activated kinase 1-binding protein 1;Transforming growth factor beta activated kinase binding protein 1.
Fields
>>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>Osteoclast differentiation;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>TNF signaling pathway;>>Alcoholic liver disease;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Yersinia infection;>>Leishmaniasis;>>Toxoplasmosis;>>Hepatitis B;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection;>>Lipid and atherosclerosis
Human protein sequence Database
Q15750
Mouse protein sequence database
Q8CF89
Rat protein sequence database
Cellular localization
nucleoplasm,cytoplasm,cytosol,endosome membrane,protein complex,
Tissue expression
Ubiquitous.
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