Molecular weight (DA)
47kD
Immunogen
Recombinant protein corresponding to fragment (aa/225-430) GOT2 .
Specificity
This antibody detects endogenous levels of GOT2.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013],
Function
catalytic activity:L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.,cofactor:Pyridoxal phosphate.,function:Facilitates cellular uptake of long-chain free fatty acids.,miscellaneous:In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer.,
Other name
AATM_HUMAN ；AL022787 ；Aspartate aminotransferase ；Aspartate aminotransferase 2 ；Aspartate aminotransferase, mitochondrial ；ASPATA ；EC 2.6.1.1 ；FABP 1 ；FABP pm ；FABP-1 ；FABPpm ；Fatty acid binding protein ；Fatty acid-binding protein ；FLJ40994 ；Glutamate oxaloacetate transaminase 2 ；Glutamate oxaloacetate transaminase 2, mitochondrial ；Glutamate oxaloacetate transaminase, mitochondrial ；Glutamic oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) ；Got 2 ；GOT2 ；KAT4 ；KATIV ；Kynurenine aminotransferase IV ；mAspAT ；MGC102129 ；MGC115763 ；mitAAT ；mitochondrial ；Mitochondrial aspartate aminotransferase ；OTTMUSP00000017748 ；Plasma membrane fatty acid binding protein ；Plasma membrane-associated fatty acid-binding protein ；Transaminase A.
Fields
>>Arginine biosynthesis;>>Alanine, aspartate and glutamate metabolism;>>Cysteine and methionine metabolism;>>Arginine and proline metabolism;>>Tyrosine metabolism;>>Phenylalanine metabolism;>>Phenylalanine, tyrosine and tryptophan biosynthesis;>>Metabolic pathways;>>Carbon metabolism;>>2-Oxocarboxylic acid metabolism;>>Biosynthesis of amino acids;>>Fat digestion and absorption
Human protein sequence Database
P00505
Mouse protein sequence database
P05202
Rat protein sequence database
Cellular localization
Mitochondrion matrix . Cell membrane . Exposure to alcohol promotes translocation to the cell membrane. .
Tissue expression
Epithelium,Gastric mucosa,Muscle,
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