Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RPS3. AA range:171-220
Specificity
Ribosomal Protein S3 Polyclonal Antibody detects endogenous levels of Ribosomal Protein S3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and
Function
similarity:Belongs to the ribosomal protein S3P family.,similarity:Contains 1 KH type-2 domain.,
Protein name
40S ribosomal protein S3
Abbreviation
Ribosomal Protein S3
Other name
RPS3; OK/SW-cl.26; 40S ribosomal protein S3
Fields
>>Ribosome;>>Pathogenic Escherichia coli infection;>>Salmonella infection;>>Coronavirus disease - COVID-19
Human protein sequence Database
P23396
Mouse protein sequence database
P62908
Rat protein sequence database
P62909
Cellular localization
Cytoplasm . Nucleus . Nucleus, nucleolus . Mitochondrion inner membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, spindle . In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity). Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537). Localizes to the spindle during mitosis (PubMed:23131551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). .
Tissue expression
Adrenal cortex,Cervix carcinoma,Colon adenocarcinoma,Epithelium,Liver,Lymph,Pituita
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