Molecular weight (DA)
22kD
Immunogen
Purified recombinant human GADD45 α protein expressed in E.coli
Specificity
Transfected Only.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb dilution 1:1000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010],
Function
disease:Induction of GADD45 in ataxia telangiectasia cells is abnormal.,function:Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.,induction:By UV radiation, X-rays, growth arrest and alkylating agents. The induction is mediate by some kinase(s) other than PKC.,similarity:Belongs to the GADD45 family.,subunit:Interacts with GADD45GIP1.,
Other name
DDIT 1; DDIT-1; DDIT1; DNA damage inducible transcript 1; DNA damage-inducible transcript 1 protein; GA45A_HUMAN; GADD45; GADD45A; Growth arrest and DNA damage inducible 45 alpha; Growth arrest and DNA damage inducible alpha; Growth arrest and DNA damage-inducible protein GADD45 alpha.
Fields
>>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>FoxO signaling pathway;>>Cell cycle;>>p53 signaling pathway;>>Apoptosis;>>Cellular senescence;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Colorectal cancer;>>Pancreatic cancer;>>Endometrial cancer;>>Glioma;>>Thyroid cancer;>>Basal cell carcinoma;>>Melanoma;>>Chronic myeloid leukemia;>>Small cell lung cancer;>>Non-small cell lung cancer;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer
Human protein sequence Database
P24522
Mouse protein sequence database
P48316
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Bronchial epithelial cells treated with 20 uM arsenic for 4
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