Molecular weight (DA)
36kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CAH11 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008],
Function
function:Does not have a catalytic activity.,similarity:Belongs to the alpha-carbonic anhydrase family.,tissue specificity:Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.,
Gene Name
CA11 CARP2 UNQ211/PRO237
Protein name
Carbonic anhydrase-related protein 11 (CA-RP XI) (CA-XI) (CARP XI) (Carbonic anhydrase-related protein 2) (CA-RP II) (CARP-2)
Human protein sequence Database
O75493
Mouse protein sequence database
O70354
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.
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