Molecular weight (DA)
262kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 430-510
Specificity
NAV3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008],
Function
developmental stage:Expressed in fetal brain.,disease:Defects in NAV3 may be a cause of mycosis fungoides [MIM:254400]; a malignant T-cell lymphoma of the skin.,disease:Defects in NAV3 may be a cause of Sezary syndrome, a malignant T-cell lymphoma of the skin.,function:May regulate IL2 production by T-cells. May be involved in neuron regeneration.,similarity:Belongs to the Nav/unc-53 family.,similarity:Contains 1 CH (calponin-homology) domain.,tissue specificity:Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.,
Gene Name
NAV3 KIAA0938 POMFIL1 STEERIN3
Protein name
Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3)
Human protein sequence Database
Q8IVL0
Mouse protein sequence database
Q80TN7
Rat protein sequence database
Cellular localization
Nucleus outer membrane .
Tissue expression
Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.
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