Molecular weight (DA)
57kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 292-342
Specificity
DC1L1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016],
Function
function:May play a role in binding dynein to membranous organelles or chromosomes. May associate with the heavy chains in the dynein head where they might regulate enzyme activity.,PTM:Phosphorylated.,similarity:Belongs to the dynein light intermediate chain family.,subunit:Consists of at least 3 heavy chains (alpha, beta and gamma), 2 intermediate chains and 8 light chains.,
Gene Name
DYNC1LI1 DNCLI1
Protein name
Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic)
Fields
>>Phagosome;>>Vasopressin-regulated water reabsorption;>>Salmonella infection
Human protein sequence Database
Q9Y6G9
Mouse protein sequence database
Q8R1Q8
Rat protein sequence database
Q9QXU8
Cellular localization
Cytoplasm . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle pole .
Tissue expression
Cerebellum,Coronary artery,Epithelium,Human testis,
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