Immunogen
Synthesized peptide derived from human AKIR2 AA range: 14-64
Specificity
This antibody detects endogenous levels of AKIR2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1.,miscellaneous:'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.,similarity:Belongs to the akirin family.,subunit:Interacts with YWHAB.,tissue specificity:Widely expressed with the highest expression in peripheral blood leukocytes.,
Gene Name
AKIRIN2 C6orf166
Human protein sequence Database
Q53H80
Mouse protein sequence database
B1AXD8
Rat protein sequence database
Q25C79
Cellular localization
Nucleus . Cytoplasm . Membrane . Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. .
Tissue expression
Widely expressed with the highest expression in peripheral blood leukocytes.
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