Immunogen
Synthesized peptide derived from human ACPH AA range: 255-305
Specificity
This antibody detects endogenous levels of ACPH at Human/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.,function:This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.,mass spectrometry: PubMed:10395453,similarity:Belongs to the peptidase S9C family.,subunit:Homotetramer.,
Gene Name
APEH D3F15S2 D3S48E DNF15S2
Human protein sequence Database
P13798
Mouse protein sequence database
Rat protein sequence database
P13676
Cellular localization
Cytoplasm.
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