Immunogen
Synthesized peptide derived from human SPRE3 AA range: 311-361
Specificity
This antibody detects endogenous levels of SPRE3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012],
Function
function:Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.,PTM:Phosphorylated on tyrosine.,similarity:Contains 1 SPR (sprouty) domain.,similarity:Contains 1 WH1 domain.,subunit:Interacts with Ras.,
Human protein sequence Database
Q2MJR0
Mouse protein sequence database
Q6P6N5
Rat protein sequence database
Cellular localization
Cell membrane ; Peripheral membrane protein .
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