Immunogen
Synthesized peptide derived from human KHK AA range: 102-152
Specificity
This antibody detects endogenous levels of KHK at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + D-fructose = ADP + D-fructose 1-phosphate.,caution:Form C has not yet been fully sequenced in its N-terminal (from 1-69).,disease:Defects in KHK are the cause of fructosuria [MIM:229800]. Fructosuria is a benign defect of intermediary metabolism.,enzyme regulation:Requires potassium. Inhibition by ADP.,pathway:Carbohydrate metabolism; fructose metabolism.,similarity:Belongs to the carbohydrate kinase pfkB family.,subunit:Dimer of A-A, A-C or C-C.,tissue specificity:Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.,
Fields
>>Fructose and mannose metabolism;>>Metabolic pathways
Human protein sequence Database
P50053
Mouse protein sequence database
P97328
Rat protein sequence database
Q02974
Cellular localization
cytoplasm,cytosol,extracellular exosome,
Tissue expression
Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.
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