Immunogen
Synthesized peptide derived from human NMNA3 AA range: 97-147
Specificity
This antibody detects endogenous levels of NMNA3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],
Function
catalytic activity:ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).,catalytic activity:ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+).,cofactor:Divalent metal cations. Magnesium confers the highest activity.,enzyme regulation:Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD).,function:Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotina
Fields
>>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors
Human protein sequence Database
Q96T66
Mouse protein sequence database
Q99JR6
Rat protein sequence database
Cellular localization
Mitochondrion .
Tissue expression
Expressed in lung and spleen with lower levels in placenta and kidney.
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