Immunogen
Synthesized peptide derived from human NOVA2 AA range: 274-324
Specificity
This antibody detects endogenous levels of NOVA2 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
disease:Autoantigen in the paraneoplastic opsoclonus myoclonus ataxia (POMA), a paraneoplastic neurological syndrome/disorder (PNS/D) associated with breast cancer, fallopian cancer, and SCLCa and characterized primarily by loss of inhibitory control of motor neurons in the spinal cord and brainstem. Recognized by the IgG autoantibody ANNA-2 (also called anti-Ri).,domain:The third KH domain (KH3) recognizes specifically 5'-UCAY-3'.,function:May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.,similarity:Contains 3 KH domains.,subunit:Interacts with PTBP2.,tissue specificity:Brain. Expression restricted to astrocytes.,
Gene Name
NOVA2 ANOVA NOVA3
Human protein sequence Database
Q9UNW9
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Brain. Expression restricted to astrocytes.