Immunogen
Synthesized peptide derived from human ALG1 AA range: 180-230
Specificity
This antibody detects endogenous levels of ALG1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provided by RefSeq, Dec 2008],
Function
catalytic activity:GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.,disease:Defects in ALG1 are the cause of congenital disorder of glycosylation type 1K (CDG1K) [MIM:608540]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.,function:Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembli
Gene Name
ALG1 HMAT1 HMT1 PSEC0061 UNQ861/PRO1870
Fields
>>N-Glycan biosynthesis;>>Various types of N-glycan biosynthesis;>>Metabolic pathways
Human protein sequence Database
Q9BT22
Mouse protein sequence database
Q921Q3
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
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